Antioxidant enzymes and vascular diseases

Reactive oxygen species (ROS) and reactive nitrogen (RNS) play a fundamental role in regulating endothelial function vascular tone the physiological conditions of system. However, oxidative stress has detrimental effects on human health, numerous studies confirmed that high ROS/RNS production contributes to initiation progression cardiovascular diseases. The antioxidant defense an essential homeostatic functioning Endogenous antioxidative includes various molecules enzymes such as superoxide dismutase, catalase, glutathione reductase, peroxidase. Together all these are for against harmful ROS features. mainly generated from redox-active compounds involved mitochondrial respiratory chain. Thus, targeting mitochondria balance may be promising approach diseases occurrence treatment. This review summarized most recent research regulation